Bromocriptine Scavenges Methamphetamine‐induced Hydroxyl Radicals and Attenuates Dopamine Depletion in Mouse Striatum a

doi:10.1111/j.1749-6632.1994.tb21807.x

Paper

Bromocriptine Scavenges Methamphetamine‐induced Hydroxyl Radicals and Attenuates Dopamine Depletion in Mouse Striatum a

Published Nov 1, 1994 · T. Kondo, Takashi Ito, Y. Sugita

Annals of the New York Academy of Sciences

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70

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2

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Abstract

Methamphetamine is known to induce dopaminergic toxicity in the mouse. Free-radical generation has been postulated as one possible mechanism of the toxicity of methamphetamine (MA) in dopaminergic neurons.'-3 A previous report indicated the possibility of measuring free radical generation using ~alicylate.~ Salicylate is converted to 2,3and 2,s-dihydroxybenzoic acid (DHBA) by reaction with hydroxyl radicals. Using this method, in vivo measurements of hydroxyl radicals have been r e p ~ r t e d . ~ , ~ We have demonstrated that the toxicity of MA to dopaminergic neurons is mediated by hydroxyl radical generation by measuring 2,3and 2,5-DHBA.'vs According to our previous results, 2,3-DHBA is a more reliable indicator of toxicity than 2,5-DHBA. Bromocriptine mesilate is a dopamine (DA) D2 receptor agonist. In general, according to the dopamine-derived free radical hypothesis:JO substances which exhibit D2 agonistic action are expected to protect the DA neurons by attenuation of DA turnover rate through autoreceptor activation"-'3. However, a new role of this substance as a free radical scavenger has been reported.I4 Yoshikawa et al. demonstrated, using ESR, that bromocriptine scavenges superoxide anion and hydroxyl radicals. The action of bromocriptine as a free radical scavenger may be comparable to that of vitamin E.I4 In this paper, we confirm our earlier findings regarding MA-induced formation of hydroxyl radicals in the striatum, as evidenced by an increased production of 2,3-DHBA in response to peripherally administered salicylate. Additionally, we show that bromocriptine, a D2 agonist, is capable of attenuating the striatal dopamine depletion and increased 2,3-DHBA production resulting from treatment with MA. We attribute these effects of bromocriptine to its ability to scavenge free radicals formed in response to MA administration.

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Study Snapshot

Bromocriptine, a D2 receptor agonist, can reduce striatal dopamine depletion and hydroxyl radical generation caused by methamphetamine treatment, potentially offering a potential treatment for dopaminergic neurotoxicity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Bromocriptine Scavenges Methamphetamine‐induced Hydroxyl Radicals and Attenuates Dopamine Depletion in Mouse Striatum a

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References

Antioxidant Properties of Bromocriptine, a Dopamine Agonist

Bromocriptine, a widely used Parkinson's disease treatment, is a potent antioxidant that effectively scavenges free radicals and reduces brain oxidation.

Chronic dietary pergolide preserves nigrostriatal neuronal integrity in aged-Fischer-344 rats

Chronic dietary pergolide administration for 2 years protects against age-related deterioration of dopaminergic nigrostriatal neurons, potentially benefiting Parkinson's disease patients.

Evaluation of the effects of inhibition of monoamine oxidase and senescence on methamphetamine-induced neuronal damage

Inhibiting monoamine oxidase type A and B increases methamphetamine-induced neuronal damage, and aged mice are more sensitive to its toxic effects.

Conditions influencing yield and analysis of 8-hydroxy-2'-deoxyguanosine in oxidatively damaged DNA.

Storage at 20°C at neutral or acidic pH prevents loss of 8-OHdG in oxidatively damaged DNA, while storage at 20°C at alkaline pH leads to significant loss.

Aromatic hydroxylation as a potential measure of hydroxyl-radical formation in vivo. Identification of hydroxylated derivatives of salicylate in human body fluids.

This study suggests that hydroxylation of salicylate into 2,3-dihydroxybenzoate, or other aromatic compounds, may serve as a useful assay for measuring hydroxyl-radical formation in the human body.

Citations

Neuroprotection in Parkinson’s disease: facts and hopes

Neuroprotective agents show promise in preclinical and clinical studies, but more research is needed to find the optimal treatment for Parkinson's disease.

Methyl jasmonate abrogates rotenone-induced parkinsonian-like symptoms through inhibition of oxidative stress, release of pro-inflammatory cytokines, and down-regulation of immnopositive cells of NF-κB and α-synuclein expressions in mice.

Methyl jasmonate reduces Parkinson's-like symptoms in mice by inhibiting oxidative stress, reducing pro-inflammatory cytokines, and down-regulating NF-B and -synuclein expressions.

Bromocriptine Mesylate Attenuates Amyotrophic Lateral Sclerosis: A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Research in Japanese Patients

Bromocriptine mesylate shows potential in maintaining motor function and communication in ALS patients when combined with Riluzole.

NEUROPROTECTIVE STUDIES ON THE MPTP AND SOD1 MOUSE MODELS OF NEURODEGENERATIVE DISEASES

Estrogen treatment restores immunity in male mice after burn injury with prior ethanol exposure, potentially benefiting neuroprotective studies in neurodegenerative diseases.

Molecular and cellular bases for the protective effects of dopamine D1 receptor antagonist, SCH23390, against methamphetamine-induced neurotoxicity in the rat brain

SCH23390 effectively blocks methamphetamine-induced neurotoxicity in the rat brain by inhibiting ER and mitochondrial stresses, while raclopride only partially blocks these effects.