Paper
Butylated hydroxyanisole isomers induce distinct adipogenesis in 3T3-L1 cells.
Published Nov 5, 2019 · Zhendong Sun, Xiaoxi Yang, Qian S. Liu
Journal of hazardous materials
Q1 SJR score
38
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
3-BHA and BHA promote adipogenesis and lipid accumulation through interference with the upstream events of the PPAR signaling pathway, potentially contributing to obesity.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
Quantitative identification of and exposure to synthetic phenolic antioxidants, including butylated hydroxytoluene, in urine.
BHT levels were high in urine samples from Japan, India, and the United States, suggesting potential human exposure to synthetic phenolic antioxidants.
2019·88citations·Wei Wang et al.·Environment international
Environment international
Synthetic phenolic antioxidants and their major metabolites in human fingernail
Synthetic phenolic antioxidants (SPAs) are present in human fingernails, with BHT being the predominant compound, suggesting their bioaccumulation potential in the human body.
2019·46citations·Chao Li et al.·Environmental Research
Environmental Research
Developmental toxicity of synthetic phenolic antioxidants to the early life stage of zebrafish.
Synthetic phenolic antioxidants (SPAs) can cause developmental toxicities in zebrafish, with AO2246 being the most toxic, followed by TBHQ, BHA, and BHT, and affecting heart rates, body lengths, and morphological deformities.
2018·127citations·Xiaoxi Yang et al.·The Science of the total environment
The Science of the total environment
Synthetic Phenolic Antioxidants and Transformation Products in Human Sera from United States Donors
Synthetic phenolic antioxidants BHT and DBP are found at significant concentrations in human serum, with potential biotransformation products indicating potential toxicity.
2018·74citations·Runzeng Liu et al.·Environmental Science and Technology Letters
Environmental Science and Technology Letters
Effects of Perinatal Exposure to Dibutyltin Chloride on Fat and Glucose Metabolism in Mice, and Molecular Mechanisms, in Vitro
DBT exposure during perinatal development can increase fat storage, leptin levels, and glucose intolerance in mice, potentially contributing to the rise of metabolic disorders in humans.
2018·37citations·Raquel Chamorro-Garcia et al.·Environmental Health Perspectives
Environmental Health Perspectives
Chlorinated Polyfluorinated Ether Sulfonates Exhibit Higher Activity toward Peroxisome Proliferator-Activated Receptors Signaling Pathways than Perfluorooctanesulfonate.
Cl-PFAESs, as PFOS alternatives, exhibit higher activity toward PPARs signaling pathways, highlighting potential health risks for workers.
2018·106citations·Chuan-Hai Li et al.·Environmental science & technology
Environmental science & technology
Inventory, loading and discharge of synthetic phenolic antioxidants and their metabolites in wastewater treatment plants.
Synthetic phenolic antioxidants, particularly BHT, are present in wastewater treatment plants, with personal care products accounting for over 91% of their mass loading source.
2018·53citations·Wei Wang et al.·Water research
Water research
Synthetic Phenolic Antioxidants Cause Perturbation in Steroidogenesis in Vitro and in Vivo.
Synthetic phenolic antioxidants, particularly BHA, can cause disruption in steroidogenesis at low concentrations, highlighting their potential endocrine disrupting effects.
2018·96citations·Xiaoxi Yang et al.·Environmental science & technology
Environmental science & technology
Adiposity and reproductive cycling status in zoo African elephants
Zoo African elephants with abnormal reproductive cycles are associated with increased adiposity, potentially mediated by glucose, insulin, leptin, and inflammation.
2017·14citations·Daniella E. Chusyd et al.·Obesity (Silver Spring, Md.)
Obesity (Silver Spring, Md.)
Citations
Modelling the Repair of Carbon-Centered Protein Radicals by Phenolic Antioxidants
Phenolic antioxidants can repair carbon-centered protein radicals through formal-hydrogen atom transfer, but single electron transfer is not a significant pathway for the studied phenols.
2024·0citations·Max Walton-Raaby et al.·Antioxidants
Antioxidants
Adipogenic Effects of Cresyl Diphenyl Phosphate (Triphenyl Phosphate Alternative) through Peroxisome Proliferator-Activated Receptor Gamma Pathway: A Comprehensive Study Integrating In Vitro, In Vivo, and In Silico from Molecule to Health Risk.
Cresyl diphenyl phosphate (CDP) activates PPAR, promoting preadipocyte differentiation and white adipose tissue development, with potential obesogenic risks of high concern.
2024·1citation·Lanchao Sun et al.·Environmental science & technology
Environmental science & technology
Health effects of synthetic additives and the substitution potential of plant-based additives.
This report explores the safety assessment and toxicity studies of common synthetic additives and the potential health benefits of plant-based alternatives, offering insights for sustainable food additive development.
2024·0citations·Jiaqi Chen et al.·Food research international
Food research international
Assessment of the disruption effects of tetrabromobisphenol A and its analogues on lipid metabolism using multiple in vitro models.
TBBPA analogues may disrupt lipid metabolism in various tissues, potentially causing obesity, non-alcoholic fatty liver disease, and other lipid metabolism disorders when combined with high-fat diets.
2024·1citation·Zhiwen Li et al.·Ecotoxicology and environmental safety
Ecotoxicology and environmental safety
Subchronic co-exposure of polystyrene nanoplastics and 3-BHA significantly aggravated the reproductive toxicity of ovaries and uterus in female mice.
Co-exposure of nanoplastics and 3-BHA significantly worsens reproductive toxicity in female mice, mainly through the FSTL1-mediated BMP4/TGF-/SMAD signaling pathway.
2024·1citation·Guanghua Xiong et al.·Environmental pollution
Environmental pollution
Gut dysbiosis contributes to SCFAs reduction-associated adipose tissue macrophage polarization in gestational diabetes mellitus.
Gut dysbiosis contributes to adipose tissue inflammation and insulin resistance in gestational diabetes mellitus by reducing bacterial products SCFAs.
2024·4citations·Hongli Li et al.·Life sciences
Life sciences
Unveiling the anti-oxidative potential of fruits and vegetables waste in prolonging the shelf stability of vegetable oils
Incorporating natural antioxidants from fruits and vegetable waste effectively enhances the oxidative stability of edible vegetable oils, offering a safer and more eco-friendly alternative to synthetic antioxidants.
2024·10citations·Muqaddas Zahid et al.·Future Foods
Future Foods
Environmental Obesogens and Their Perturbations in Lipid Metabolism
Environmental obesogens, which include more than 50 chemicals, can interfere with lipid metabolism and induce obesity, with multiple targets and influencing factors.
2024·10citations·Xiaoyun Wang et al.·Environment & Health
Environment & Health
Degradation of Butylated Hydroxyanisole by the Combined Use of Peroxymonosulfate and Ferrate(VI): Reaction Kinetics, Mechanism and Toxicity Evaluation
The combination of peroxymonosulfate and Ferrate(VI) effectively reduces the environmental risk of butylated hydroxyanisole degradation and improves degradation efficiency in water treatment applications.
2024·14citations·Peiduan Shi et al.·Toxics
Toxics