M. Bootman
2012
Citations
164
Influential Citations
3,396
Citations
Quality indicators
Journal
Cold Spring Harbor perspectives in biology
Abstract
Calcium ions regulate processes as diverse as cell motility, gene transcription, muscle contraction, and exocytosis (Berridge et al. 2000). The first realization that they are critical for cellular function is often attributed to Sydney Ringer, who discovered in 1883 that saline solution made up using London tap water (which contained calcium) supported the contraction of isolated frog hearts, whereas saline made up using distilled water (which lacked calcium) could not. Subsequent work revealed that numerous cell biological processes are controlled by calcium (Carafoli