Cannabis therapy in neurological disorders: Recent advances and perspectives

doi:10.37897/RJPHP.2020.4.1

Paper

Cannabis therapy in neurological disorders: Recent advances and perspectives

Published Dec 31, 2020 · Alexandru Mandici, I. Pharmacy, Daniel Cojocariu

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Abstract

Both phytocannabinoids (Δ9-tetrahydrocannabinol, cannabidiol) and synthetic derivatives (nabilone, dronabinol) showed therapeutic benefits in some neurological disorders. Cannabis inhalation was reported to attenuate several symptoms (rigidity, bradykinesia, tremor) in Parkinson’s disease. A significant reduction in monthly seizures in patients with epilepsy has been noted for cannabidiol, while administration of Δ9-tetrahydrocannabinol resulted in benefits on psychomotor agitation in patients suffering from Alzheimer’s disease. Although there are clinical studies supporting the use of cannabis preparations as adjuvant therapy in neurological disorders, more investigations are needed to assess their safety and efficacy.

Study Snapshot

Key takeawayCannabis preparations show potential therapeutic benefits in neurological disorders, including Parkinson's disease, epilepsy, and Alzheimer's disease.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Cannabis therapy in neurological disorders: Recent advances and perspectives

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References

Cannabinoids and the expanded endocannabinoid system in neurological disorders

Cannabinoids and endocannabinoids show potential as therapeutic treatments for various neurological disorders, including Parkinson's disease, Alzheimer's disease, multiple sclerosis, and epilepsy.

Sativex in the management of multiple sclerosis-related spasticity: An overview of the last decade of clinical evaluation.

Sativex is an effective and safe treatment for multiple sclerosis-related spasticity, improving patient quality of life and offering a new option for those resistant to common antispastic drugs.

Cannabis, cannabinoids, and health

Cannabis use has harmful psychiatric and addictive effects, with increased potency and synthetic cannabinoids posing additional dangers, while some cannabinoids have therapeutic properties.

Trial of Cannabidiol for Drug‐Resistant Seizures in the Dravet Syndrome

Cannabidiol effectively reduced convulsive seizures in Dravet syndrome patients, but was associated with higher rates of adverse events.

Cannabis and Pain: A Clinical Review

Cannabis pharmacotherapy for pain shows modest evidence of effectiveness, but more research is needed to address potential side effects and risks.

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