Capromorelin, a ghrelin receptor agonist, increases feed intake and body weight gain in broiler chickens (Gallus gallus domesticus)

doi:10.1016/j.psj.2021.101204

Paper

Capromorelin, a ghrelin receptor agonist, increases feed intake and body weight gain in broiler chickens (Gallus gallus domesticus)

Published Apr 20, 2021 · N. Ceron-Romero, N. Taofeek, A. Thomas

Poultry Science

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7

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0

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Abstract

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RCT

Animal Study

Rigorous Journal

Study Snapshot

Capromorelin linearly increases feed intake and body weight gain in broiler chickens, similar to its orexigenic effects in mammals.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Capromorelin, a ghrelin receptor agonist, increases feed intake and body weight gain in broiler chickens (Gallus gallus domesticus)

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References

Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode

The crystal structure of the ghrelin receptor bound to antagonist suggests a possible mechanism for activation by acyl-modified ghrelin, including the interaction between the gap structure and acyl acid moiety.

The anorexigenic effect of beta-melanocyte-stimulating hormone involves corticotrophin-releasing factor and mesotocin in birds

Central injection of -MSH effectively reduces food intake in chickens, with changes in mRNA expression of anorexigenic factors occurring in a hypothalamic nucleus-specific manner.

Brain accessibility delineates the central effects of circulating ghrelin

Circulating ghrelin accessibility into the brain is low and restricted to specific areas, potentially impacting its central effects and physiological implications.

Real-Time Monitoring

Mirador ExpressTM is a fully customizable, web-based system for real-time monitoring of temperature, humidity, differential pressure, and carbon dioxide in pharmaceutical facilities.

Ghrelin serves as a signal of energy utilization and is involved in maintaining energy homeostasis in broilers.

Ghrelin serves as a signal of energy utilization in chickens, with its abundance in liver and abdominal fat pad potentially affecting energy balance.

Citations

Effect of Capromorelin on Appetite and Weight Gain of Domestic Pigeons (Columba livia domestica).

Capromorelin effectively stimulates appetite and weight gain in domestic pigeons, with no adverse side effects observed.

Linking gastrointestinal tract structure, function, and gene expression signatures to growth variability in broilers: a novel interpretation for flock uniformity

Growth rates in broiler chickens are linked to intestinal size, structure, and function, offering insights into the underlying mechanisms regulating body weight.

The effect of dietary sodium octanoate on Ghrelin concentration and feed intake in chickens and turkeys: a comparative study

Sodium octanoate administration leads to a differential response in feed intake and body weight gain in chickens and turkeys.

Update on Feeding Regulation by Ghrelin in Birds: Focused on Brain Network

Ghrelin regulates feeding behavior in birds differently from mammals, with urocortin playing a key role in the inhibitory mechanism.

Detection of capromorelin in urine following oral and dermal routes of administration.

Incidental exposure to capromorelin through oral or dermal routes can result in detectable levels in urine, highlighting the risk for athletes and testing authorities.