Capturing a sulfenic acid with arylboronic acids and benzoxaborole.

doi:10.1021/ja407628a

Paper

Capturing a sulfenic acid with arylboronic acids and benzoxaborole.

Published Sep 19, 2013 · C. Liu, S. Benkovic

Journal of the American Chemical Society

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31

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Abstract

Post-translational redox generation of cysteine-sulfenic acids (Cys-SOH) functions as an important reversible regulatory mechanism for many biological functions, such as signal transduction, balancing cellular redox states, catalysis, and gene transcription. Herein we show that arylboronic acids and cyclic benzoxaboroles can form adducts with sulfenic acids in aqueous medium and that these boron-based compounds can potentially be used to trap biologically significant sulfenic acids. As proof of principle we demonstrate that a benzoxaborole can inhibit the enzyme activity of an iron-containing nitrile hydratase, which requires a catalytic αCys114-SOH in the active site. The nature of the adduct and the effect of the boronic acid's pK(a)(B) on the stability constant of the adduct are discussed within.

Study Snapshot

Arylboronic acids and cyclic benzoxaboroles can trap biologically significant sulfenic acids, potentially affecting signal transduction and gene transcription.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Capturing a sulfenic acid with arylboronic acids and benzoxaborole.

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References

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Citations

Trapping an Ester Hydrate Intermediate in a π-Stacked Macrocycle with Multiple Hydrogen Bonds

Ester hydrate intermediates can be trapped and stabilized in a -stacked macrocycle with multiple hydrogen bonds, enabling their crystal structures to be characterized.

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