Carbamazepine is an inhibitor of histone deacetylases.

doi:10.1016/J.LFS.2005.01.003

Paper

Carbamazepine is an inhibitor of histone deacetylases.

Published May 13, 2005 · A. Beutler, Side Li, R. Nicol

Life sciences

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106

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4

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Highly Cited

Study Snapshot

Carbamazepine, a common antiepileptic drug, may contribute to its pharmacological profile by inhibiting histone deacetylases, potentially contributing to its teratogenicity and mood stabilization properties.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Carbamazepine is an inhibitor of histone deacetylases.

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References

The Activity of Antiepileptic Drugs as Histone Deacetylase Inhibitors

Traditional and newer antiepileptic drugs show varying levels of activity as HDAC inhibitors, with valproic acid showing the highest activity.

Selective Growth Inhibition of Tumor Cells by a Novel Histone Deacetylase Inhibitor, NVP-LAQ824

NVP-LAQ824 selectively inhibits tumor cell growth and induces apoptosis in cancer cells, making it a potential anticancer agent in clinical trials.

Search for a common mechanism of mood stabilizers.

Mood stabilizers like lithium and valproic acid may share a common mechanism of action, but the molecular origins of bipolar disorder remain unclear.

Cross-Reactivity Assessment of Carbamazepine-10,11-epoxide, Oxcarbazepine, and 10-Hydroxy-Carbazepine in Two Automated Carbamazepine Immunoassays: PETINIA and EMIT 2000

The PETINIA assay can falsely increase CBZ levels due to its high cross-reactivity with CBZ-E, while the EMIT 2000 shows satisfactory specificity and low cross-reactivity with OCBZ and HCBZ.

Apicidin, a histone deacetylase inhibitor, induces differentiation of HL-60 cells.

Apicidin inhibits cell growth and induces early differentiation of HL-60 cells, potentially playing a role in cancer cell progression.

Citations