Carbazole Scaffold in Medicinal Chemistry and Natural Products: A Review from 2010-2015.

doi:10.2174/1568026615666150915112647

Paper

Carbazole Scaffold in Medicinal Chemistry and Natural Products: A Review from 2010-2015.

Published May 1, 2016 · L. S. Tsutsumi, D. Gündisch, Dianqing Sun

Current topics in medicinal chemistry

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75

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Abstract

9H-carbazole is an aromatic molecule that is tricyclic in nature, with two benzene rings fused onto a 5-membered pyrrole ring. Obtained from natural sources or by synthetic routes, this scaffold has gained much interest due to its wide range of biological activity upon modifications, including antibacterial, antimalarial, anticancer, and anti-Alzheimer properties. This review reports a survey of the literature on carbazole-containing molecules and their medicinal activities from 2010 through 2015. In particular, we focus on their in vitro and in vivo activities and summarize structure-activity relationships (SAR), mechanisms of action, and/or cytotoxicity/selectivity findings when available to provide future guidance for the development of clinically useful agents from this template.

Literature Review

Highly Cited

Study Snapshot

Carbazole-containing molecules show potential as antibacterial, antimalarial, anticancer, and anti-Alzheimer agents when modified, offering potential for clinical development.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Carbazole Scaffold in Medicinal Chemistry and Natural Products: A Review from 2010-2015.

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