Cardamom supplementation improves inflammatory and oxidative stress biomarkers in hyperlipidemic, overweight, and obese pre-diabetic women: a randomized double-blind clinical trial.

doi:10.1002/jsfa.8414

Paper

Cardamom supplementation improves inflammatory and oxidative stress biomarkers in hyperlipidemic, overweight, and obese pre-diabetic women: a randomized double-blind clinical trial.

Published Dec 1, 2017 · S. Kazemi, Fatemeh Yaghooblou, F. Siassi

Journal of the science of food and agriculture

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33

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2

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Abstract

BACKGROUND Several preclinical studies have shown that spices may decrease the risk of chronic diseases. However, it has been suggested that more clinical trials be carried out to strengthen this preclinical evidence. The purpose of the present study was to evaluate the effects of cardamom (Elettaria cardamomum) supplementation on inflammation and oxidative stress in hyperlipidemic, overweight, and obese pre-diabetic women. METHODS This randomized, placebo-controlled, double-blind clinical trial was conducted on 80 pre-diabetic subjects. They randomly received the cardamom supplement (n = 40, 3 g d-1 ) or identical inert placebo (n = 40) for 8 weeks. Serum concentrations of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumour necrosis factor α, total antioxidant capacity, malondialdehyde (MDA), protein carbonyl, and erythrocyte superoxide dismutase and glutathione reductase activity were analyzed at the baseline and after intervention. RESULTS After the adjustment of some covariates, cardamom supplementation significantly decreased serum hs-CRP (P = 0.02), hs-CRP:IL-6 ratio (P = 0.008), and MDA (P = 0.009) compared with the placebo group. CONCLUSION Cardamom could improve some parameters of inflammation and oxidative stress in pre-diabetic subjects. Thus it may be useful in reducing complications associated with inflammation and oxidative stress in these patients. Copyright © 2017 Society of Chemical Industry © 2017 Society of Chemical Industry.

RCT

Rigorous Journal

Study Snapshot

Cardamom supplementation may improve inflammation and oxidative stress biomarkers in pre-diabetic women, potentially reducing complications associated with inflammation and oxidative stress.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Cardamom supplementation improves inflammatory and oxidative stress biomarkers in hyperlipidemic, overweight, and obese pre-diabetic women: a randomized double-blind clinical trial.

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References

Protective Effects of Cardamom in Isoproterenol-Induced Myocardial Infarction in Rats

Cardamom significantly protects the heart and exerts cardioprotective effects by free radical scavenging and antioxidant activities in isoproterenol-induced myocardial infarction in rats.

Arterial stiffness and endothelial inflammation in prediabetes and newly diagnosed diabetes patients.

E-selectin levels increase with serum glucose levels and arterial stiffness in prediabetes and newly diagnosed diabetes patients, potentially predicting future cardiovascular events.

Effect of different training mode on Interleukin-6 (IL-6) and C-reactive protein (CRP) in type 2 diabetes mellitus (T2DM) patients

Circuit training may be an effective training mode for helping to decrease blood inflammatory factors (IL-6 and CRP) in patients with type 2 diabetes mellitus.

Chronic Diseases Caused by Chronic Inflammation Require Chronic Treatment: Anti-inflammatory Role of Dietary Spices

Dietary spices, such as cardamonin, curcumin, capsaicin, gingerol, thymoquinone, and piperine, show potential in suppressing chronic inflammation and preventing the development of chronic diseases.

High-Sensitivity C-Reactive Protein and Interleukin-6–Dominant Inflammation and Ischemic Stroke Risk: The Northern Manhattan Study

Elevated high-sensitivity C-reactive protein (hsCRP) is associated with an increased risk of ischemic stroke, while low hsCRP is associated with a decreased risk in the Northern Manhattan Study.

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