T cell functions are impaired by inhaled isobutyl nitrite through a T-independent mechanism.

doi:10.1016/0378-4274(94)90126-0

Paper

T cell functions are impaired by inhaled isobutyl nitrite through a T-independent mechanism.

Published Feb 15, 1994 · L. Soderberg

Toxicology letters

Q2 SJR score

29

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0

Influential Citations

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

Inhaled isobutyl nitrite significantly reduces T cell-mediated immune responses, with cytotoxic T lymphocyte activity and proliferation responses being significantly impaired.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

T cell functions are impaired by inhaled isobutyl nitrite through a T-independent mechanism.

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References

Inhaled isobutyl nitrite compromises T-dependent, but not T-independent, antibody induction.

Inhaled isobutyl nitrite impairs T-dependent antibody induction, but not T-independent, and is reversible, with normal immune responses returning within 5-7 days.

The immunopathogenesis of human immunodeficiency virus infection.

HIV infection causes severe immunosuppression by causing functional abnormalities and quantitative depletion of CD4 T lymphocytes, leading to clinical disease.

Analysis of role of CD8+ T cells in resistance to murine AIDS in A/J mice.

CD8+ T cells play a critical role in resistance to murine AIDS in A/J mice, suggesting that CD4+ T cells play a role in ecotropic virus replication regulation.

Prechronic inhalation toxicity studies of isobutyl nitrite

A concentration of 150 ppm could be used as the highest exposure level for chronic inhalation tests, indicating potential health risks at higher concentrations.

Cytokine regulation of bone marrow natural suppressor cell activity in the suppression of lymphocyte function.

Cytokine regulation of bone marrow natural suppressor cells plays a crucial role in suppressing immune responses and maintaining bone marrow homeostasis.

Citations

The Brain Immune Axis and Substance Abuse

Substance abuse directly and indirectly affects the immune system, with effects mediated by the central nervous system and neuroendocrine system.

Inhalants abuse: Status of etiology and intervention

Inhalants are widely available, legal, inexpensive, and easily obtained, but little research has tested prevention or treatment programs specifically for inhalant abuse.

Reliability of use, abuse, and dependence of four types of inhalants in adolescents and young adults.

Inhalant abuse is more common than dependence in adolescents and young adults, with abuse criteria and diagnosis resolving issues, but dependence criteria and diagnoses need improvement.

Inhalant abuse in the military: an unrecognized threat.

Inhalant abuse is a prevalent but often overlooked substance abuse in the military, due to factors such as high availability, low cost, lack of drug screening and treatment programs, and frequent misdiagnosis by clinicians.

Effects of Inhalant Nitrites on VEGF Expression: A Feasible Link to Kaposi's Sarcoma?

Inhalant nitrites may contribute to the development of Kaposi's sarcoma by stimulating VEGF expression, potentially explaining the link between their use and the cancer.