P. R. Oliveira, L. Bernardi, F. S. Murakami
Aug 6, 2009
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0
Influential Citations
24
Citations
Journal
Journal of Thermal Analysis and Calorimetry
Abstract
Norfloxacin (NFX) is a synthetic antibacterial drug. The development of extended release tablets improves the patients’ comfort and compliance, resulting in lower discontinuation of the therapy; with consequently decrease in bacterial resistance. In the present work, the thermal behavior of NFX was investigated using TG and DSC techniques. Isothermal and non-isothermal methods were employed to determine kinetic data of decomposition process. Compatibility studies between NFX and pharmaceutical excipients, including three hydrophilic polymers were carried out in order to develop a new formulation of NFX to obtain extended release tablets with an approved quality.