Characterization of an insecticidal coumarin from Boenninghausenia albiflora

doi:10.1002/ptr.1909

Paper

Characterization of an insecticidal coumarin from Boenninghausenia albiflora

Published Jul 1, 2006 · Rajnikant Sharma, D. Negi, W. Shiu

Phytotherapy Research

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27

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1

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Abstract

The leaves of Boenninghausenia albiflora afforded an insecticidal coumarin which was identified as murraxocin (7‐methoxy‐8‐[1′‐ethoxy‐2′‐hydroxy‐3′‐methyl‐but‐3′enyl]‐coumarin) (1), on the basis of extensive 1‐ and 2‐dimensional NMR experiments. This compound has previously been isolated from Murraya exotica but this is the first report of the full 1H and 13C data for this compound. This natural product was evaluated against important forest insect pests and was active against Plecoptera reflexa, Clostera cupreata and Crypsiptya coclesalis at different concentrations varying from 1.0% to 5% w/v. In the crude extract 70% mortality was observed, and for compound 1 80% mortality was observed at a concentration of 1.0% w/v. The percentage of insect mortality increased in a dose‐dependent manner. Coumarins are poorly studied insecticides and there is potential to exploit this chemically simple group of natural products. Copyright © 2006 John Wiley & Sons, Ltd.

Study Snapshot

Murraxocin, a natural product from Boenninghausenia albiflora leaves, effectively kills forest insect pests, with potential for further exploration as a potential insecticide.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Characterization of an insecticidal coumarin from Boenninghausenia albiflora

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