J. Lei
2010
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Journal
Journal of Isotopes
Abstract
Methacetin-methoxy-13C was synthesized by using methanol-13C with a novel method,and the characterization of it was performed using HPLC,LC-MS and 1HMNR.The results indicated that the synthetic was right.And the yield of methacetin-methoxy-13C was 70.0% with 99% 13C abundance and 99.8% purity.Compared with the classical method,there was more benefit.The methacetin 13C-breath test was performed with the synthetic on the live mice,which showed a precise reflection of alteration of liver function in liver injury and functional recovery.