V. Dorokhov, L. Vasil’ev, F. E. Surzhikov
Jul 1, 1995
Citations
0
Influential Citations
7
Citations
Journal
Russian Chemical Bulletin
Abstract
Ethyl 2-acetyl-3-amino-4,4,4-trifluoro-2-butenoate was synthesized by treatment of ethyl acetoacetate with CF3CN in the presence of Ni(acac)2. Condensation of the diphenylboron chelate of the former with dimethylformamide dimethylacetal followed by refluxing in ethanol yielded 3-ethoxycarbonyl-4-hydroxy-2-trifluoromethylpyridine.