Fck Chiu, R. Brownlee, Phillips
1993
Citations
0
Influential Citations
7
Citations
Journal
Australian Journal of Chemistry
Abstract
The synthesis of Nα-protected Nω-acridin-9-yl derivatives of the α,w-diamino carboxylic acids ornithine and lysine is reported. Direct introduction of the acridin-9-yl moiety to the amino side chain of the free amino acid was achieved in methanol through temporary copper(II) chelation protection of the α-amino and carboxy groups. Nα-Fmoc protection was introduced by using N-(fluoren-9-ylmethoxycarbonyloxy)succinimide in aqueous dioxan.