K. Mogilaiah, K. Srinivas, G. Sudhakar
Sep 1, 2004
Citations
0
Influential Citations
4
Citations
Journal
ChemInform
Abstract
3-Phenyl-1,8-naphthyridin-2(1H)-one 1 on reaction with ethyl chloroacetate affords ethyl (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl)acetate 2, which on treatment with hydrazine hydrate yields (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl)acetic acid hydrazide 3. The acid hydrazide 3 reacts with various aromatic aldehydes to give the corresponding (2-oxo-3-phenyl-2H[1,8]naphthyridin-l-yl)acetic acid arylidenehydrazides 4. Oxidative cyclization of 4 with chloramine-T furnishes 1-(5-aryl[ ,3,4]-oxadiazol-2-ylmethyl)-3-phenyl-1H-[1,8]naphthyridin-2-ones 5. These compounds have been characterized on the basis of elemental analyses, IR, 1 H NMR and MS. Compounds 5 have been screened for their antibacterial activity.