N. Yi-cheng
2013
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Journal
Chinese Journal of Medical Imaging Technology
Abstract
Objective To assess the effectiveness of manganese chloride tetrahydrate as an oral manganese-based contrast agent for biliary obstruction in rat models,and to compare it with Gd-DTPA.Methods Thirty-two male Sprague Dawley(SD) rats were divided into 4 groups: Group 1,bileduct ligated+manganese chloride tetrahydrate;group 2,bile duct ligated+Gd-DTPA;group 3,sham+manganese chloride tetrahydrate;group 4,sham+Gd-DTPA.T1WI were obtained before and 12 h,24 h,48 h after the administration of manganese chloride tetrahydrate(2 mmol/kg) in group 1 and group 3.Group 2 and group 4 were examined with plain T1W and T1W+contrast enhanced TIW MR scanning,while T1WI was obtained again 24 h after intravenous injection of Gd-DTPA.Results In sham group,the signal intensities obtained from the livers returned to plain values 24 h after intragastric administration of manganese chloride tetrahydrate.The liver intensities in model group with manganese chloride tetrahydrate increased at all scanning time,of which the signals reached the highest level after 24 h.In sham and model group,the liver intensities all increased at T1W+contrast enhanced after intravenous injection of Gd-DTPA and normalized after 24 h.Conclusion The signal enhancement in the liver by manganese chloride tetrahydrate in rats is stronger than that of Gd-DTPA.MR scanning can be performed 24 h after oral administration of manganese chloride tetrahydrate to diagnose biliary obstruction of rat models.