Effect of chlorine substitution on the structure and activity of 4-phenylthiosemicarbazide: crystal and molecular structure of 4-(4-chlorophenyl)thiosemicarbazide

doi:10.1039/P29840001729

Paper

Effect of chlorine substitution on the structure and activity of 4-phenylthiosemicarbazide: crystal and molecular structure of 4-(4-chlorophenyl)thiosemicarbazide

Published Mar 12, 1985 · A. Nandi, S. Chaudhuri, S. Mazumdar

Journal of The Chemical Society-perkin Transactions 1

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31

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Abstract

The crystal structure of 4-(4-chlorophenyl)thiosemicarbazide has been determined by direct methods. This p-chloro-substituted 4-phenylthiosemicarbazide, with greater antibacterial activity than its unsubstituted precursor, crystallises in the space group P21/c with a= 14.594(4), b= 10.495(5), c= 12.384(4)A, β= 104.73(2)°, Z= 8, Dc= 1.469 g cm–3, and µ(Mo-Kα)= 5.83 cm–1. The structure has been refined using 1 967 reflections with I 3σ(I). The antibacterial activity of both the present compound and its precursor has been attributed to electron delocalisatoin in the thiosemicarbazide moiety enhancing both its donor and reductive capacities.

Study Snapshot

The crystal structure of 4-(4-chlorophenyl)thiosemicarbazide reveals its greater antibacterial activity due to electron delocalization in the thiosemicarbazide moiety.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Effect of chlorine substitution on the structure and activity of 4-phenylthiosemicarbazide: crystal and molecular structure of 4-(4-chlorophenyl)thiosemicarbazide

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References

Citations

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