Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight‐obese individuals consuming pomegranate: A randomized clinical trial

doi:10.1002/mnfr.201600830

Sign up

Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight‐obese individuals consuming pomegranate: A randomized clinical trial

Published May 1, 2017 · A. González‐Sarrías, R. García-Villalba, M. Romo-Vaquero

Molecular Nutrition & Food Research

Q1 SJR score

163

Citations

5

Influential Citations

Full text

Semantic Scholar

Abstract

Scope: The pomegranate lipid‐lowering properties remain controversial, probably due to the interindividual variability in polyphenol (ellagitannins) metabolism. Objective: We aimed at investigating whether the microbially derived ellagitannin‐metabolizing phenotypes, i.e. urolithin metabotypes A, (UM‐A), B (UM‐B), and 0 (UM‐0), influence the effects of pomegranate extract (PE) consumption on 18 cardiovascular risk biomarkers in healthy overweight‐obese individuals. Methods and results: A double‐blind, crossover, dose–response, randomized, placebo‐controlled trial was conducted. The study (POMEcardio) consisted of two test phases (dose‐1 and dose‐2, lasting 3 weeks each) and a 3‐week washout period between each phase. Forty‐nine participants (BMI > 27 kg/m2) daily consumed one (dose‐1, 160 mg phenolics/day) or four (dose‐2, 640 mg phenolics/day) PE or placebo capsules. Notably, UM‐B individuals showed the highest baseline cardiovascular risk. After dose‐2, total cholesterol (–15.5 ± 3.7%), LDL‐cholesterol (–14.9 ± 2.1%), small LDL‐cholesterol (–47 ± 7%), non‐HDL‐cholesterol (–11.3 ± 2.5%), apolipoprotein‐B (–12 ± 2.2%), and oxidized LDL‐cholesterol –24 ± 2.5%) dose dependently decreased (P < 0.05) but only in UM‐B subjects. These effects were partially correlated with urolithin production and the increase in Gordonibacter levels. Three (50%) nonproducers (UM‐0) became producers following PE consumption. Conclusions: UM clustering suggests a personalized effect of ellagitannin‐containing foods and could explain the controversial pomegranate benefits. Research on the specific role of urolithins and the microbiota associated with each UM is warranted.

RCT

Very Rigorous Journal

Highly Cited

Study Snapshot

Key takeawayPomegranate extract consumption improves cardiovascular risk biomarkers in overweight individuals, with urolithin metabotypes influencing the personalized effects of ellagitannin-containing foods.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Sign up or log in to use Study Snapshot and unlock more functionality.

Sign up or log in

Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight‐obese individuals consuming pomegranate: A randomized clinical trial

Sign up to use Study Snapshot

References

Addressing the inter‐individual variation in response to consumption of plant food bioactives: Towards a better understanding of their role in healthy aging and cardiometabolic risk reduction

Inter-individual variation in plant food bioactives' health benefits is crucial for optimizing their beneficial effects on age-related chronic diseases and cardiometabolic risk reduction.

Interactions of gut microbiota with dietary polyphenols and consequences to human health

Gut microbiota interactions with dietary polyphenols influence their health effects, and study participants' polyphenol-metabolizing phenotypes should be considered in clinical trials to better understand their health effects.

Lipid profile changes after pomegranate consumption: A systematic review and meta-analysis of randomized controlled trials.

Pomegranate consumption does not show a significant effect on lipid profile in humans, but may have an inverse association with triglycerides levels.

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

Urolithin A, found in pomegranate fruit, extends lifespan, improves muscle function, and may have health benefits for humans.

Diet–microbiota interactions as moderators of human metabolism

Gut microbiota plays a key role in regulating human metabolism and obesity, potentially guiding personalized nutrition strategies.

Citations

Ellagic acid ameliorates alcohol-induced cognitive and social dysfunction through the gut microbiota-mediated CCL21-CCR7 axis.

Ellagic acid improves alcohol-induced cognitive and social dysfunction by regulating the cytokine-cytokine receptor interaction pathway through gut microbiota-mediated CCL21-CCR7 axis.

Strawberry (Fragaria x Ananassa) intake on human health and disease outcomes: a comprehensive literature review.

Daily strawberry intake can improve lipid metabolism and inflammation in individuals at increased cardiovascular risk.

Pomegranate Juice Supplemented with Inulin Modulates Gut Microbiota and Promotes the Production of Microbiota-Associated Metabolites in Overweight/Obese Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial.

Pomegranate juice supplemented with inulin effectively modifies gut microbiota composition and promotes the production of beneficial metabolites in overweight/obese individuals.

Dietary supplements: clinical cholesterol-lowering efficacy and potential mechanisms of action

Dietary supplements, such as phytosterols, berberine, and polyphenol extracts, can significantly reduce plasma cholesterol levels by 3-25% in hypercholesterolemic patients, working through various mechanisms.

Inter-Individual Responses to a Blueberry Intervention across Multiple Endpoints

Inter-individual variation in vascular health and cognitive outcomes after a blueberry intervention, with no consistent response and no predictive urinary metabolite identified.

Exploring substrate–microbe interactions: a metabiotic approach toward developing targeted synbiotic compositions

Developing synbiotic compositions that guide microbial metabolism can potentially create a new category of hybrid nutra-/pharmaceuticals that improve gut health and promote individual responses to food and pharmaceutical ingredients.