Co‐delivery of miR‐181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma

doi:10.1016/j.jconrel.2019.02.014

Paper

Co‐delivery of miR‐181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma

Published Mar 1, 2019 · Seyed Nasrollah Tabatabaei, R. Derbali, Chun Yang

Journal of Controlled Release

Q1 SJR score

70

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2

Influential Citations

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Highly Cited

Study Snapshot

Co-delivery of melphalan and miR-181a in lipid nanoparticles significantly improves therapeutic efficiency and reduces side-effects in treating retinoblastoma.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Co‐delivery of miR‐181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma

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References

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Recent developments in ophthalmic drug delivery systems, using hydrogels as carriers, have improved drug delivery efficacy and biocompatibility for treating eye diseases.

Lipid Nanoparticle Formulations for Enhanced Co-delivery of siRNA and mRNA.

Co-formulation of siRNA and mRNA in lipid nanoparticles enhances the efficacy of both drugs in treating diseases, with a negatively charged "helper polymer" also improving delivery efficiency.

Overcoming ocular drug delivery barriers through the use of physical forces

Physical methods like electrical fields, sonophoresis, and microneedles can enhance ocular drug delivery by transiently disrupting ocular barriers in a minimally invasive manner.

Citations