E. Peets, D. A. Buyske
Oct 1, 1964
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Influential Citations
31
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Journal
Biochemical pharmacology
Abstract
Abstract The absorption, excretion, and metabolism of the d - and l -isomers of 14 C-labeled 2,2'-(ethylenediimino)-di-1-butanol have been studied. Both isomers disappear rapidly from the plasma after i.v. or oral administration in the dog, with the d -isomer being removed more rapidly from the circulation than the 1. The drug accumulates in or on the erythrocytes. Differences in the excretion of the two isomers also exist; 97% of an intravenous dose of the d -isomer is recovered from the excreta as compared with 81% of the dose of the l -isomer, Both isomers are metabolized by the dog to two compounds: (1) an intermediate metabolite aldehydic in nature and (2) a dicarboxylic acid -2,2'-(ethylenediimino)-di-butyric acid corresponding to the terminal oxidation product of the parent compound. The extent of metabolism of the l -isomer is greater than that of the d in the dog. Alcohol dehydrogenase and the soluble and microsomal fractions of rat liver convert the drug to an aldehyde, similar in nature to the primary metabolite.