G. Abdulina, A. Gazaliev, G. Baikenova
Mar 1, 2002
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0
Influential Citations
2
Citations
Journal
Pharmaceutical Chemistry Journal
Abstract
The alkaloid anabasine is known as an effective insecticide and was widely used against various harmful insects in agriculture in 1930 – 1960s [1, 2]. As the organophosphorus insecticides appeared in 1960s, the production of anabasine was prohibited because of its high toxicity. However, some of the anabasine derivatives possess antibacterial activity [2, 3] in combination with moderate toxicity. In continuation of the previous investigations [3] related to the search for new biologically active substances possessing low toxicity, we have performed a comparative study of the antibacterial and antifungal activity of anabasine hydrochloride (I) and anabasine O,O-dialkylthiophosphates (II – V).