E. C. Herrmann, J. A. Herrmann, D. Delong
Dec 1, 1981
Citations
0
Influential Citations
21
Citations
Quality indicators
Journal
Antiviral Research
Abstract
Abstract 6-[[(Hydroxyimino)phenyl]methyl]-1-[(1-methylethyl)sulfonyl]-1 H -benzimidazole-2-amine (LY-122771-72) was substantially more active (and more toxic) than 2-(α-hydroxybenzyl) benzimidazole (HBB) and guanidine-HC1 in a microtiter assay system employing the inhibition of the cytopathic effect produced by 13 enteroviruses. In cell cultures HBB and guanidine were mutually ‘synergistic’ for each other but neither had a similar effect on LY122771-72 or its close relative LY127123. A mixture of HBB and guanidine when injected into infant mice would save them from the lethal effects of infections with coxsackie A9 and echo 9 viruses. It was further found that the substituted benzimidazoles LY122771-72 and LY127123, when given daily for 9 days, could save significant numbers of mice from death caused by echo 9, coxsackie A9 and A16 viruses. HBB alone was significantly effective in the treatment of mice infected with echo 9 and coxsackie A9 but not coxsackie A16 virus. Guanidine alone was effective treatment for mice infected with either echo 9 or coxsackie A16 viruses with striking activity against this latter infection, requiring only a 4 day treatment starting 58 h after virus inoculation.