Pang Sujuan
2009
Citations
0
Influential Citations
0
Citations
Journal
Chemical Reagents
Abstract
At present,there are two routes to synthesize levetiracetam by use of(S)-2-aminobutanamide hydrochloride as a chiral resource.In the first route,the target compound is synthesized by reaction of(S)-2-aminobutanamide hydrochloride with ethyl 4-bromobutyrate via nucleophilic reaction and cyclization.In the second way,the target compound is also obtained by reaction of(S)-2-aminobutanamide hydrochloride with 4-chlorobutyryl chloride via amidation and cyclization in the presence of base and phase transfer catalyst.The results showed that diacetylation impurity amount was high and therefore reaction time was too long for the first route,the most reason is that diacetylation impurity is difficult to be removed.Comparably,for the second route,there was no diacetylation impurity and therefore reaction time was shorter than that for the first route,the most reason is that PEG-400 is used as a phase transfer catalyst,so,this method is simple and easy for industrial application.