Shun-ichiro Uesugi, Y. Sasano, Shogo Matsui
2017
Citations
0
Influential Citations
2
Citations
Journal
Chemical & pharmaceutical bulletin
Abstract
A concise, protecting-group-free synthesis of the antipsychotic agent (+)-nemonapride has been achieved featuring a europium(III) trifluoromethanesulfonate (Eu(OTf)3)-catalyzed C4 selective aminolysis of a 3,4-epoxy alcohol by benzylamine and an expedient use of the resulting 4-benzylamino-1,3-diol product for constructing the pyrrolidine skeleton.