G. Muller, W. Konnecke, and Alison M. Smith
Mar 19, 1999
Citations
1
Influential Citations
47
Citations
Journal
Organic Process Research & Development
Abstract
A two-step synthesis of thalidomide is presented. The sequence requires no purifications. Treatment of l-glutamine with N-carbethoxyphthalimide produces N-phthaloyl-l-glutamine. Cyclization of N-phthaloyl-l-glutamine to afford thalidomide is accomplished by treatment with CDI in the presence of a catalytic amount of DMAP.