J. Aguirre, A. Ibañez, E. Alesso
Aug 25, 1988
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Influential Citations
2
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Journal
Chemical & Pharmaceutical Bulletin
Abstract
Several N-(monosubstituted ethyl)amides were synthesized and their carbon and proton nuclear magnetic resonance (13C and 1H-NMR) spectra were determined. Both (Z) and (E) stereoisomers could be observed in the formamides, but only the (Z) isomer was identified in the acetamides and phenylacetamides. The main body of the 1H-NMR results indicated that the methylene protons were equivalent. This finding is interpreted in terms of free rotation around the -CH2-CH-bond and magnetic equivalence. In cases where the 1H-NMR spectra revealed and ABX pattern, an interpretation is offered based on different populations among "pure staggered"conformers.