G. Birnbaum, R. Roy, J. Brisson
Mar 1, 1987
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Journal
Journal of Carbohydrate Chemistry
Abstract
Abstract Ammonium 3-deoxy-D-manno-2-octulosonate monohydrate (KDO) crystallizes in the orthorhombic space group P212121, and the cell dimensions are a - 6.9700(4)A, b = 7.7230(4) A, c = 23.4067 (12) A. X-ray intensity data were measured on a diffractometer, and the structure was determined by direct methods. Least-squares refinement, which included all hydrogen atoms, converged at R = 0.034 for 1526 observed reflections. The pyranose ring exists in an almost perfect 5C2 (D) chair conformation. The COO-, 4-OH and 6-CHOHCH2OH groups are In equatorial orientation, while the 2-OH and 5-OH groups are axial. The solution conformations of the ammonium salts of methyl α- and β-ketopyranosides of KDO were determined by high-resolution 1H NMR spectroscopy. The conformation of the ethylene glycol side chain in the α-methyl glycopyranoside of KDO was found to be indistinguishable from that in the solid state. However, the solution conformation of the side chain is different in the β-anomer, possibly indicative of an ...