Jenifer L. Smith, K. I. Rossiter, Christopher M. Semko
Jul 15, 2013
Citations
1
Influential Citations
3
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
Mitsunobu reactions were employed to link t-butyl esters of α4 integrin inhibitors at each of the termini of a three-arm, 40 kDa, branched PEG. Cleavage of the t-butyl esters using HCO2H provided easily isolated PEG derivatives, which are potent α4 integrin inhibitors, and which achieve sustained levels and bioactivity in vivo, following subcutaneous administration to rats.