Yurii Yu. Kozyrkov, A. Pukin, O. Kulinkovich
Aug 12, 2000
Citations
0
Influential Citations
10
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The diastereoselective titanium(IV)-mediated cyclopropanation of ethyl 3,3-diethoxypropionate by Grignard reagents, followed by modified Knoevenagel condensation with malonic acid under microwave irradiation, allow the preparation of ( E )-1-(1-alkenyl)cyclopropanol derivatives, suitable precursors of π-1,1-dimethyleneallylmetal species. The azidation of such complexes, followed by a reduction–oxidation sequence led to pure ( E )-2,3-methanoamino acids.