Tianwen Li, P. Shang, Chang-mei Cheng
Jan 9, 2013
Citations
0
Influential Citations
4
Citations
Journal
Tetrahedron Letters
Abstract
A convenient one-pot synthesis of enantiopure (R)-2-amino-3,3,3-trifluoro-2-methyl-N-phenylpropanamide derivatives has been developed. The key step in this synthetic methodology turned out to be the amide formation in which (R)-2-amino-3,3,3-trifluoro-2-methylpropanoic acid hydrochloride was simultaneously protected and activated by Vilsmeier reagent.