James R. Vyvyan, Jennifer A. Meyer, Korin D. Meyer
Oct 14, 2003
Citations
0
Influential Citations
35
Citations
Journal
The Journal of organic chemistry
Abstract
Anhydrous tin(II) chloride is an efficient catalyst for the reaction of epoxides with acetone to prepare 2,2-dimethyl-1,3-dioxolanes (acetonides) in good to excellent yields. Mono-, di-, and trisubstituted epoxides participate equally well in this diastereospecific reaction. The use of single enantiomer epoxides under the reported conditions results in significant erosion of optical activity.