Copper(I) complexes with phosphine derived from sparfloxacin. Part II: a first insight into the cytotoxic action mode.

doi:10.1039/c5dt04011f

Paper

Copper(I) complexes with phosphine derived from sparfloxacin. Part II: a first insight into the cytotoxic action mode.

Published Mar 15, 2016 · U. K. Komarnicka, R. Starosta, M. Płotek

Dalton transactions

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54

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Abstract

In this paper we present a first insight into the cytotoxic action mode of copper(I) iodide or copper(I) thiocyanate complexes with a phosphine derivative of sparfloxacin (a 3rd generation fluoroquinolone antibiotic agent) and 2,9-dimethyl-1,10-phenanthroline or 2,2'-biquinoline as auxiliary ligands. The in vitro cytotoxic activity of the new complexes was tested against two cancer cell lines (CT26--mouse colon carcinoma and A549--human lung adenocarcinoma). An ICP-MS study revealed a marked time-dependent intracellular copper accumulation of the tested compounds. In addition, confocal microscopy imaging showed accumulation of the complexes inside whole cells and their emission of blue light. The complexes generate reactive oxygen species in the cancer cells, which was examined by using two different fluorescent probes. Moreover, (I) DNA intercalation studied by luminescence spectroscopy, circular dichroism and molecular docking, and (II) plasmid DNA damage also demonstrate their significant cytotoxicity. All these observed biological effects contribute to the induction of apoptosis, observed at a great predominance.

In Vitro Study

Study Snapshot

Copper(I) complexes with phosphine derivatives from sparfloxacin effectively induce apoptosis in cancer cells by generating reactive oxygen species, DNA intercalation, and plasmid DNA damage.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Copper(I) complexes with phosphine derived from sparfloxacin. Part II: a first insight into the cytotoxic action mode.

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References

Coordination versatility of phosphine derivatives of fluoroquinolones. New CuI and CuII complexes and their interactions with DNA

Copper(I) and copper(II) complexes with phosphine derivatives of fluoroquinolones show diverse interactions with DNA, causing single-stranded cleavage and plasmid damage, respectively.

Phosphine derivatives of sparfloxacin – Synthesis, structures and in vitro activity

Sparfloxacin derivatives PSf and OPSf show similar antibacterial activity and increased cytotoxicity against various cancer cell lines, with OPSf showing the highest cytotoxicity.

DNA/protein binding, DNA cleavage, cytotoxicity, superoxide radical scavenging and molecular docking studies of copper(II) complexes containing N-benzyl-N′-aryl-N′′-benzoylguanidine ligands

Copper(II) complexes with N,N′,N′′-trisubstituted guanidine ligands show good cytotoxic activity against cancer cell lines and significant superoxide radical scavenging activity.

Copper(i) complexes with phosphine derived from sparfloxacin. Part I - structures, spectroscopic properties and cytotoxicity.

Copper(i) complexes with phosphine derived from sparfloxacin show promising biological properties, with dmp complexes showing strong inhibitory properties and bq complexes not showing such properties.

Biophysical characterization and molecular docking studies of imidazolium based polyelectrolytes-DNA complexes: role of hydrophobicity.

Imidazolium-based polyelectrolytes-DNA complexes show potential for nonviral gene therapy due to their efficient binding and ability to retain DNA's B-form.

Citations

Docking Studies, Cytotoxicity Evaluation and Interactions of Binuclear Copper(II) Complexes with S-Isoalkyl Derivatives of Thiosalicylic Acid with Some Relevant Biomolecules

Copper(II) complexes with S-isoamyl derivative of thiosalicylic acid show the highest cytotoxic effect and reduced tumor growth and metastases in a colon cancer model.

Anticandidal Cu(I) complexes with neocuproine and 1-(4-methoxyphenyl)piperazine based diphenylaminomethylphosphine: Is Cu-diimine moiety a pharmacophore?

Copper(I) complexes with neocuproine and 1-(4-methoxyphenyl)piperazine show promising antifungal activity against Candida albicans, with a MIC 50 value of 0.4 M.

New N4-Donor Ligands as Supramolecular Guests for DNA and RNA: Synthesis, Structural Characterization, In Silico, Spectrophotometric and Antimicrobial Studies

New N4-donor compounds show promising nucleic acid-modulating and antimicrobial properties, with the thiazolecarboxaldehyde derivative L1 showing higher binding affinity with DNA than RNA.

A binuclear Cu(I)-phosphine complex as a specific HSA site I binder: synthesis, X-ray structure determination, and a comprehensive HSA interaction analysis

The novel binuclear Cu(I) phosphine complex shows strong binding to HSA, with its binding site being close to warfarin's specific ligand site I in HSA.

Cu(I)-Phospine complex exhibits temperature-dependent DNA intercalative binding: Insights from spectroscopic and molecular modeling studies

The Cu(I) phosphine complex exhibits temperature-dependent DNA intercalative binding, with van der Waals forces as the primary binding mechanism.

Quinolones as a Potential Drug in Genitourinary Cancer Treatment—A Literature Review

Quinolones show promising properties in bladder cancer treatment, but require combination therapy with other chemotherapeutics for prostate cancer due to low concentrations achievable in prostate tissue.

The Tail Wags the Dog: The Far Periphery of the Coordination Environment Manipulates the Photophysical Properties of Heteroleptic Cu(I) Complexes

The peripheral ligands of Cu(I) complexes significantly affect their photophysical properties, allowing for the design of new materials with controlled optoelectronic properties.

Two out of Three Musketeers Fight against Cancer: Synthesis, Physicochemical, and Biological Properties of Phosphino CuI, RuII, IrIII Complexes

Phosphino CuI, RuII, and IrIII complexes show promising cytotoxicity against cancer cells, with IC50 values significantly lower than cisplatin, and exhibit low genotoxicity towards plasmid DNA.