Brajendra Kumar Singh, Prasad Appukkuttan, Stijn Claerhout
2006
Citations
0
Influential Citations
54
Citations
Journal
Organic letters
Abstract
[reaction: see text] Optimized conditions for the decoration of the 2(1H)-pyrazinone scaffold were developed by applying the Chan-Lam protocol. It was demonstrated that this Cu(II)-mediated cross-coupling reaction resulted in significantly improved yields and rates when performed under microwave irradiation with simultaneous cooling at 0 degrees C, applying a mixture of bases Et(3)N/pyridine.