Could Inflammaging and Its Sequelae Be Prevented or Mitigated?

doi:10.2147/CIA.S235595

Paper

Could Inflammaging and Its Sequelae Be Prevented or Mitigated?

Published Dec 1, 2019 · M. Man, P. Elias

Clinical Interventions in Aging

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Abstract

Abstract Aged humans display a chronic and low-grade inflammation, termed “inflammaging”, which has been potentially linked to the subsequent development of some aging-associated systemic disorders, including type 2 diabetes, atherosclerotic cardiovascular disease, Alzheimer’s disease and obesity. Though the origin of aging-associated systemic inflammation is uncertain, epidemiological studies show that inflammatory dermatoses (psoriasis and eczema) are risk factors for some aging-associated systemic disorders, such as type 2 diabetes and atherosclerotic cardiovascular disease. Moreover, recent studies demonstrate that epidermal dysfunction in aged skin not only causes cutaneous inflammation, but also a subsequent increase in circulating levels of proinflammatory cytokines, suggesting that the skin could be a major contributor to inflammaging. This hypothesis is further supported by reductions in circulating levels of proinflammatory cytokines in both aged humans and murine, following improvements in epidermal function with topical emollients. Therefore, correction of epidermal dysfunction could be a novel approach for the prevention and mitigation of certain inflammation-associated chronic disorders in aged humans.

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Study Snapshot

Correcting epidermal dysfunction in aged skin could potentially prevent and mitigate inflammation-associated chronic disorders in aged humans.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Could Inflammaging and Its Sequelae Be Prevented or Mitigated?

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Citations

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