Z. Neiman, F. Bergmann
1965
Citations
0
Influential Citations
17
Citations
Journal
Israel Journal of Chemistry
Abstract
Reaction of a 6-methylmercaptopurine with methyl iodide in an aprotic solvent gives only a single methylation product. Both the 7- and the 9-methyl derivatives are alkylated at N-3. 3-Methyl-6-methylmetcaptopurine is attacked at N-7, while the 1-methyl isomer is substituted at position 9. The course of the latter reaction depends markedly on the reaction conditions, as in the presence of an alkali carbonate alkylation takes place at N-7. The mechanism of these methylations is discussed.