N. Rahbar, Z. Ramezani, J. Ghanavati
Jun 1, 2016
Citations
1
Influential Citations
17
Citations
Journal
Chinese Chemical Letters
Abstract
Abstract In this research, copper oxide nanoparticles modified carbon paste electrode was developed for the voltammetric determination of lidocaine. The square wave voltammogram of lidocaine solution showed a well-defined peak between +0.5 and +1.5 V. Instrumental and chemical parameters influencing voltammetric response were optimized by both one at a time and Box–Behnken model of response surface methodology. The results revealed that there was no significant difference between two methods of optimization. The linear range was 1–2500 μmol L −1 ( I p = 0.11C LH + 17.38, R 2 = 0.999). The LOD and LOQ based on three and ten times of the signal to noise (S/N) were 0.39 and 1.3 μmol L −1 ( n = 10), respectively. The precision of the method was assessed for 10 replicate square wave voltammetry (SWV) determinations each of 0.05, 0.5 and 1 mmol L −1 of lidocaine showing relative standard deviations 4.1%, 3.7% and 2.1%, respectively. The reliability of the proposed method was established by application of the method for the determination of lidocaine in two pharmaceutical preparations, namely injection and gel.