R. Orth, J. Jones
Sep 1, 1962
Citations
0
Influential Citations
6
Citations
Journal
Journal of pharmaceutical sciences
Abstract
Some 1-alkyl- and 1-aryl-1,2,3,4-tetrazole-5-thiones are synthesized by preparing methyl-(N-alkyl- and N-aryl)-dithiocarbamates by dropwise addition of carbon disulfide to a cold solution of the amine in aqueous sodium hydroxide, followed by slowly esterifying, separating, and purifying the ester. Sodium azide is refluxed with the various esters forming, in several cases, the substituted tetrazole-5-thione on purification.