I. O. Feskov, Anton V. Chernykh, I. Kondratov
Nov 2, 2017
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0
Influential Citations
7
Citations
Journal
The Journal of organic chemistry
Abstract
Hitherto unknown cis- and trans-1-amino-3-hydroxy-3-methylcyclobutanecarboxylic acids were synthesized in multigram scale. The obtained compounds can be considered as achiral conformationally restricted analogues of threonine with fixed spatial orientation of functional groups. pKa values are noticeably different for both amino acids. According to the X-ray data the cyclobutane rings in both compounds are almost planar (the corresponding torsion angles are below 7°).