D. Weiss, D. Aizenberg, H. Hermesh
Oct 1, 1995
Citations
1
Influential Citations
41
Citations
Quality indicators
Journal
British Journal of Psychiatry
Abstract
Background Cyproheptadine, an antiserotonergic agent, was used to treat neuroleptic-induced akathisia. Method In an open clinical trial 17 neuroleptic-treated patients with akathisia were administered cyproheptadine (16 mg/day) over 4 days. Assessment of akathisia, psychosis and depression were monitored by BAS, BPRS and HAM-D. Results All subjects showed improvement in the severity of akathisia, which in the majority (15/17) was of a marked degree. There was no aggravation of psychosis or depression. Symptoms of akathisia returned when cyproheptadine was discontinued. Conclusions Cyproheptadine may be useful in neuroleptic-induced akathisia.