Cytotoxity and Anti- Small Cell Lung Cancer Potential of 3-Methoxy-5-Nitrosalicylaldehyde: A Analog for the Treatment of Diabetes Mellitus with Considerable Binding Affinity to α˗Amylase Enzyme

doi:10.5114/AOMS/139071

Paper

Cytotoxity and Anti- Small Cell Lung Cancer Potential of 3-Methoxy-5-Nitrosalicylaldehyde: A Analog for the Treatment of Diabetes Mellitus with Considerable Binding Affinity to α˗Amylase Enzyme

Published Jul 9, 2021 · H. Wen, Junyan Wang, Saad H. Alotaibi

Archives of Medical Science

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Abstract

Alpha-amylase inhibitors are present in plants and are thought to be produced by plants to strengthen their defenses against predators. It contains plant components, polyphenolic compounds and glycoproteins with enzymatic inhibitory activity.The molecular docking investigation was accomplished as a versatile method for the evaluation of the biological activities of 3-Methoxy-5-nitrosalicylaldehyde in the presence of alpha amylase. MTT test was used on normal (HUVEC) and small cell lung cancer (SBC-3, DMS273, and DMS114) cell lines.In this study, inhibition result of metabolic enzyme was obtained IC50: 95.14 µM. The compound exhibited a considerable binding affinity to the enzyme with a docking score of -7.676 kcal/mol. The results of the molecular docking revealed that 3-Methoxy-5-nitrosalicylaldehyde is able to construct hydrophobic contacts with crucial residues of the catalytic domain of the enzyme. According to these findings, the compound has the potential to be an inhibitor for alpha amylase. 3-Methoxy-5-Nitrosalicylaldehyde had high cell death and anti-small cell lung cancer effects against SBC-3, DMS273, and DMS114 cell lines. Among the above cell lines, the best result of anti-small cell lung cancer properties of molecule was gained in the cell line of DMS273.The results of this study indicated the excellent anti-small cell lung cancer potentials of 3-Methoxy-5-Nitrosalicylaldehyde in the in vitro condition. After confirming the above results in the clinical trial researches, this formulation may be administrated for the treatment of several types of small cell lung cancer in humans.

In Vitro Study

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Study Snapshot

3-Methoxy-5-nitrosalicylaldehyde shows excellent anti-small cell lung cancer potential, with potential for use in treating various types of small cell lung cancer.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Cytotoxity and Anti- Small Cell Lung Cancer Potential of 3-Methoxy-5-Nitrosalicylaldehyde: A Analog for the Treatment of Diabetes Mellitus with Considerable Binding Affinity to α˗Amylase Enzyme

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References

Evaluation of potential anti-RNA-dependent RNA polymerase (RdRP) drugs against the newly emerged model of COVID-19 RdRP using computational methods

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Efficient biogenesis of Cu2O nanoparticles using extract of Camellia sinensis leaf: Evaluation of catalytic, cytotoxicity, antioxidant, and anti-human ovarian cancer properties.

Copper nanoparticles green-synthesized by Camellia sinensis leaf extract show potential as a chemotherapeutic material for human ovarian cancers, with high cell death and anti-human ovarian cancer properties.

Alpha-Amylase and Alpha-Glucosidase Enzyme Inhibition and Antioxidant Potential of 3-Oxolupenal and Katononic Acid Isolated from Nuxia oppositifolia

Nuxia oppositifolia plant extracts show potential antidiabetic and antioxidant activities, with 3-oxolupenal showing more potent inhibition against -glucosidase and katononic acid showing low to moderate antioxidant activity.

Novel C-2 Symmetric Molecules as α-Glucosidase and α-Amylase Inhibitors: Design, Synthesis, Kinetic Evaluation, Molecular Docking and Pharmacokinetics

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The involvement of phenolic-rich extracts from Galician autochthonous extra-virgin olive oils against the α-glucosidase and α-amylase inhibition.

Galician extra-virgin olive oils, 'Brava' and 'Mansa de Figueiredo', contain high concentrations of phenolic acids and flavonoids, potentially offering health benefits against diabetes mellitus.

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