Selective decontamination of the digestive tract with aztreonam: a study of 10 healthy volunteers.

doi:10.1093/INFDIS/150.5.636

Paper

Selective decontamination of the digestive tract with aztreonam: a study of 10 healthy volunteers.

Published Nov 1, 1984 · H. Vries-Hospers, G. W. Welling, E. Swabb

The Journal of infectious diseases

Q1 SJR score

40

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

Aztreonam, a minimally absorbable monobactam antibiotic that is active primarily against gram-negative bacilli, was given orally to 10 healthy volunteers in three regimens: 60 mg, 300 mg, and 1,500 mg daily for five days. The regimens were administered at least two weeks apart so that the flora could return to normal. Aztreonam had no effect on oropharyngeal flora cultured every other day. Fecal cultures from volunteers receiving the 300-mg regimen yielded no gram-negative bacilli after an average of 4.4 days of treatment. Administration of the highest dose gave similar results, albeit after a shorter interval (3.0 days). None of the regimens appreciably influenced total microscopic (anaerobic) bacterial counts in the feces. However, during administration of the 1,500-mg regimen, fecal counts of enterococci increased from an average of approximately 10(4)/g to greater than 10(7)/g, and fecal counts of yeasts tended to increase by the end of the five-day treatment period. Fecal concentrations of aztreonam increased as the dose increased in eight volunteers. No aztreonam was recovered from the feces of two volunteers, perhaps because of drug inactivation.

Non-RCT

Study Snapshot

Aztreonam effectively decontaminates the digestive tract, removing gram-negative bacteria after a short treatment interval, but has no significant effect on total microscopic bacterial counts.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Selective decontamination of the digestive tract with aztreonam: a study of 10 healthy volunteers.

Sign up to use Study Snapshot

References

Citations

Monobactams: A Unique Natural Scaffold of Four-Membered Ring Skeleton, Recent Development to Clinically Overcome Infections by Multidrug- Resistant Microbes

Monobactams show significant antibacterial activity, especially against superbug microbes, and recent structural modifications have expanded their activity and potential for future development as broad-spectrum antibiotics.

Development and characterisation of an in vitro human gut model to study the biofilm mode of growth of Clostridium difficile and the indigenous gut microbiota

The in vitro human gut model shows that antimicrobial treatment for Clostridium difficile may delay response in sessile populations, potentially contributing to recurrence.

Microbiology of regressive autism.

Regressive autism may be linked to Desulfovibrio, and antimicrobial agents like penicillins and cephalosporins may predispose individuals to overgrowth of Clostridium difficile and Desulfovibrio.

Antibiotic-Associated Diarrhea and Pseudomembranous Colitis: Are They Less Common with Poorly Absorbed Antimicrobials?

Poorly absorbed antibiotics may have a decreased risk of causing antibiotic-associated diarrhea and Clostridium difficile-associated disease, and probiotics may help minimize this risk.

Effect of antibiotic therapy on the density of vancomycin-resistant enterococci in the stool of colonized patients.

Antianaerobic antibiotics promote high-density colonization in patients with vancomycin-resistant enterococci, and limiting their use may help decrease the spread of the bacteria.

Development and persistence of multi-resistance to antibiotics in bacteria; an analysis and a new approach to this urgent problem.

Maintaining intestinal microflora composition and antibiotic inactivation may help mitigate the risk of antibiotic-resistant bacteria developing and spreading, potentially benefiting patients.

Determination of enzyme activity by high-performance liquid chromatography.

HPLC is a useful tool for analyzing enzyme activity in complex biological samples like feces, with future potential for detection of new enzymes using synthetic substrates and mass spectrometry.

Colonization resistance

Colonization resistance (CR) in the bowel has improved study design and data, but some conclusions were prematurely made about the availability of antimicrobial agents without impairing CR.

Thein vitro inactivation of thirteen β-lactam antibiotics by other mechanisms than adsorption to faecal substance

In a normal population, -lactamase catalyzed hydrolysis has a small impact on the activity of -lactam antibiotics compared to non-specific adsorption to fecal compounds.