Comparative analgesic, behavioral, and dependence properties of morphine and O-(4-methoxylphenylcarbamoyl)-3-diethylaminopropiophenone oxime hydrochloride.

doi:10.1002/JPS.2600690234

Paper

Comparative analgesic, behavioral, and dependence properties of morphine and O-(4-methoxylphenylcarbamoyl)-3-diethylaminopropiophenone oxime hydrochloride.

Published Feb 1, 1980 · N. Watzman, J. Buckley

Journal of pharmaceutical sciences

Q2 SJR score

3

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0

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Abstract

The analgesic activity of O-(4-methoxylphenylcarbamoyl)-3-diethylaminopropiophenone oxime hydrochloride was investigated in Swiss--Webster mice using an electroshock technique in which the pain threshold was the minimum voltage producing tonic extension of the hindlimbs in response to an electroshock delivered to the feet. The analgesic potency of O-(4-methoxylphenylcarbamoyl)-3-diethylaminopropiophenone oxime hydrochloride was equal to, or greater than, that of morphine. Neither nalorphine nor withdrawal produced visible behavioral effects in rats treated with O-(4-methoxylphenylcarbamoyl)-3-diethylaminopropiophenone oxime hydrochloride for 21 days, suggesting that the physical dependency liability of the compound may be less than that of morphine.

Non-RCT

Animal Study

Study Snapshot

O-(4-methoxylphenylcarbamoyl)-3-diethylaminopropiophenone oxime hydrochloride has equal analgesic potency to morphine, but may have less physical dependency liability than morphine.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Comparative analgesic, behavioral, and dependence properties of morphine and O-(4-methoxylphenylcarbamoyl)-3-diethylaminopropiophenone oxime hydrochloride.

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References

The Pharmacological Basis of Therapeutics

This comprehensive pharmacology book provides up-to-date reviews on drug use, including historical background, structure-activity relationships, dosages, side effects, and therapeutic uses.

Nalorphine-induced abstinence syndrome in morphine-tolerant albino rats.

Nalorphine hydrochloride induces an abstinence syndrome in morphine-tolerant albino rats, causing sedation, loss of muscular rigidity, and increased intestinal activity.

Citations