Depigmenting Effect of Catechins

doi:10.3390/molecules14114425

Paper

Depigmenting Effect of Catechins

Published Nov 1, 2009 · Kazuomi Sato, M. Toriyama

Molecules

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67

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1

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Abstract

The aim of the present work was to clarify the anti-melanogenic mechanism of the catechin group. In this study, we used (-)-epigallocatechin-3-gallate (EGCG), (-)-epigallocatechin (EGC), (-)-catechin (C), and gallic acid (GA). The catechin group inhibited melanin synthesis in B16 melanoma cells. To elucidate the anti-melanogenic mechanism of the catechin group, we performed Western blotting analysis for crucial melanogenic protein, namely tyrosinase. The catechin group inhibited tyrosinase expression. These results indicate that the catechin group is a candidate anti-melanogenic agent and that it might be effective in hyperpigmentation disorders.

In Vitro Study

Study Snapshot

Catechins show potential as anti-melanogenic agents by inhibiting melanin synthesis and tyrosinase expression, potentially benefiting hyperpigmentation disorders.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Depigmenting Effect of Catechins

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