P. Nayak, B. Narayana, B. Sarojini
2014
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Abstract
A new 2-(4-phenylpiperazin-1-yl)-N-(pyrazin-2-yl)acetamide (4) was synthesized by the reaction of 1-phenylpiperazine (3) with 2-chloro-N-(pyrazin-2-yl)acetamide (2) in the presence of sodium hydroxide. The structure of the newly synthesized compound was characterized by IR, 1 H NMR, 13 C NMR, mass spectral and elemental analysis. The synthe- sized compound was screened for its in vitro antioxidant, in vivo analgesic and anti-inflammatory activities. The title compound exhibited noticeable DPPH radical scavenging activity, analgesic and anti-inflammatory activities in comparison with the standard.