Paper
Design and synthesis of calindol derivatives as potent and selective calcium sensing receptor agonists.
Published Feb 15, 2016 · Lionel Kiefer, F. Beaumard, T. Gorojankina
Bioorganic & medicinal chemistry
Q2 SJR score
7
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
Calindol derivatives can be designed to be more active calcium sensing receptor agonists without acting as antagonists of the related GPRC6A receptor.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Selective Allosteric Antagonists for the G Protein-Coupled Receptor GPRC6A Based on the 2-Phenylindole Privileged Structure Scaffold.
Compounds 7, 13e, and 34b are the most potent and selective antagonists for the GPRC6A receptor, with >9-fold selectivity over related GPCRs.
2015·22citations·H. Johansson et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors.
Post-translational modifications, such as glycosylation, phosphorylation, ubiquitination, SUMOylation, disulphide bonding, and lipidation, play a crucial role in regulating the structure, function, and pharmacology of class C G protein-coupled receptors
2015·29citations·Lenea Nørskov-Lauritsen et al.·European journal of pharmacology
European journal of pharmacology
Uncarboxylated osteocalcin stimulates 25-hydroxy vitamin D production in Leydig cell line through a GPRC6a-dependent pathway.
Uncarboxylated osteocalcin contributes with testosterone to 25-hydroxy vitamin D production in Leydig cells through a GPRC6a-dependent pathway.
2014·45citations·L. De Toni et al.·Endocrinology
Endocrinology
Calcium-sensing receptor 20 years later.
The calcium-sensing receptor (CaSR) plays a crucial role in regulating cellular ion transport mechanisms and influencing various diseases, with ongoing research focusing on its normal physiology and pathophysiology.
2014·88citations·Tariq I. Alfadda et al.·American journal of physiology. Cell physiology
American journal of physiology. Cell physiology
Delineation of the GPRC6A Receptor Signaling Pathways Using a Mammalian Cell Line Stably Expressing the Receptor
The GPRC6A receptor is activated by basic l--amino acids and divalent cations, and its signaling pathways are mainly mediated through the Gq pathway, with no evidence of Gi or Gs signaling.
2013·63citations·Stine E. Jacobsen et al.·The Journal of Pharmacology and Experimental Therapeutics
The Journal of Pharmacology and Experimental Therapeutics
Citations
Calcium-sensing receptor-mediated macrophage polarization improves myocardial remodeling in spontaneously hypertensive rats
R568, a positive regulator of CaSR, effectively lowers blood pressure and improves cardiac function in spontaneously hypertensive rats by promoting anti-inflammatory M2 macrophages and reducing pro-inflammatory M1 macrophages.
2024·2citations·Jiaqi Zhao et al.·Experimental Biology and Medicine
Experimental Biology and Medicine
Brønsted Acid-Catalyzed Synthesis of 4-Functionalized Tetrahydrocarbazol-1-ones from 1,4-Dicarbonylindole Derivatives
This study presents a p-toluenesulfonic acid-catalyzed cascade reaction for the synthesis of 4-functionalized tetrahydrocarbazolones from 1,4-dicarbonylindole derivatives, offering high overall yields for diverse te
2023·0citations·Sara Gómez-Gil et al.·The Journal of Organic Chemistry
The Journal of Organic Chemistry
Copper-Catalyzed Regioselective sp3 C-H Azidation of Alkyl Substituents of Indoles and Tetrahydrocarbazoles.
Copper-catalyzed regioselective sp3 C-H azidation effectively incorporates azido groups into alkyl substituents of indoles and tetrahydrocarbazoles under simple and mild reaction conditions.
2019·11citations·Liwu Huang et al.·The Journal of organic chemistry
The Journal of organic chemistry
A domino approach to pyrazino- indoles and pyrroles using vinyl selenones
This study presents a flexible and efficient method for preparing biologically relevant 3,4-dihydropyrazino[1,2-a]indol-1(2 H)ones and 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2 H)ones using vinyl
2018·11citations·M. Palomba et al.·Tetrahedron
Tetrahedron
Important roles of the Ca2+‐sensing receptor in vascular health and disease
Ca2+-sensing receptor (CaSR) plays a crucial role in regulating vascular tone and blood pressure, and its dysfunction may be associated with fatal vascular diseases.
2018·34citations·Yanjun Guo et al.·Life Sciences
Life Sciences