Design, synthesis and biological evaluation of 3-(4-halophenyl)-3-oxopropanal and their derivatives as novel antibacterial agents.

doi:10.1248/CPB.58.1127

Paper

Design, synthesis and biological evaluation of 3-(4-halophenyl)-3-oxopropanal and their derivatives as novel antibacterial agents.

Published Sep 1, 2010 · Jinbing Liu, Wei Yi, Jianming Hu

Chemical & pharmaceutical bulletin

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6

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1

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Abstract

In continuing our program aimed to search for potent drugs for bacterial infections, a series of 3-(4-halophenyl)-3-oxopropanal and their derivatives were designed, synthesized and their antibacterial activities in vitro against both Gram-positive bacteria Staphylococcus aureus and Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa were evaluated. Compounds 7, 8, 13-16, 21 and 22 had moderate antibacterial activities against Staphylococcus aureus (minimal inhibitory concentration (MIC) <16 microg/ml), suggesting that the introduction of mono-methoxyamine or ethoxyamine moiety might play an important role in determining the potent antibacterial activities. Furthermore, the antibacterial activities of select compounds 7, 15 and 16 against the clinically important pathogenic bacteria-methicillin-resistant Staphylococcus aureus (MRSA) were also investigated. Results showed that these compounds exhibited more potent activities than the well-known antibacterial agents Houttuynin and Levofloxacin.

In Vitro Study

Study Snapshot

3-(4-halophenyl)-3-oxopropanal and its derivatives show potential as novel antibacterial agents against various bacteria, including MRSA, with more potent activities than Houttuynin and Levofloxacin.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Design, synthesis and biological evaluation of 3-(4-halophenyl)-3-oxopropanal and their derivatives as novel antibacterial agents.

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References

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Citations

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Sodium houttuyfonate, derived from Houttuynia cordata Thunb, has multiple pharmacological effects, including antifungal, antibacterial, anti-inflammatory, and cardiovascular protective activities.

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This study developed a new method for synthesis of novel compounds with potent antibacterial activities against Helicobacter pylori, potentially offering a promising alternative to current drugs.

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