Paper
Design, synthesis and biological evaluation of 2-methyl-(1,1'-biphenyl)-pyrimidine conjugates.
Published Aug 15, 2020 · A. Chen, Dong Wu, Jia Shi
Bioorganic & medicinal chemistry letters
Q2 SJR score
7
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
Novel compounds with 2-methyl-(1,1'-biphenyl)-pyrimidine conjugates show strong anti-cancer effects, particularly against HepG2 cells and HT-29 cells.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
Design, synthesis of 4,5-diazafluorene derivatives and their anticancer activity via targeting telomeric DNA G-quadruplex.
4,5-diazafluorene derivatives, particularly 14c, show potential as anticancer drugs by targeting telomeric DNA G-quadruplexes and inhibiting cancer cell growth and metastasis.
2019·27citations·Kang Zhou et al.·European journal of medicinal chemistry
European journal of medicinal chemistry
Discovery of [1,2,4]Triazolo[4,3- a]pyridines as Potent Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction.
A22 is a promising lead compound for developing inhibitors of the PD-1/PD-L1 interaction, with potential for future drug design.
2019·78citations·Mingze Qin et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
Lung cancer is the most common diagnosed cancer and leading cause of death worldwide, with breast cancer being the most common diagnosed cancer among women and colorectal cancer being the leading cause of cancer death in men.
2018·69051citations·F. Bray et al.·CA: A Cancer Journal for Clinicians
CA: A Cancer Journal for Clinicians
Knockdown of TGF-β1 expression in human umbilical cord mesenchymal stem cells reverts their exosome-mediated EMT promoting effect on lung cancer cells.
Silencing TGF-1 expression in mesenchymal stem cells can revert their EMT-promoting effect and enhance their anti-proliferative and pro-apoptotic effects on lung cancer cells.
2018·76citations·Xiaoyin Zhao et al.·Cancer letters
Cancer letters
Frequencies and expression levels of programmed death ligand 1 (PD-L1) in circulating tumor RNA (ctRNA) in various cancer types.
PD-L1 mRNA can be detected and quantitated in circulating tumor RNA of cancer patients, potentially identifying those most likely to benefit from conventional treatments.
2018·50citations·Toshiyuki Ishiba et al.·Biochemical and biophysical research communications
Biochemical and biophysical research communications
Citations
Small-molecule modulators of tumor immune microenvironment.
Small-molecule modulators play a crucial role in tumor immunotherapy, enhancing immune activity and reducing immunosuppressive effects.
2024·4citations·Jing Zhang et al.·Bioorganic chemistry
Bioorganic chemistry
Diversification Via Coupling Reactions and Biological Activities of Pyrimidine Derivatives
Diversifying pyrimidine derivatives through coupling reactions improves their pharmacological properties, offering potential for creating next-generation medicines with enhanced efficacy and selectivity.
2023·11citations·Arif Ullah et al.·ChemistrySelect
ChemistrySelect
Small Molecule Agents Targeting PD-1 Checkpoint Pathway for Cancer Immunotherapy: Mechanisms of Action and Other Considerations for Their Advanced Development
Small molecule agents targeting PD-1 checkpoint pathway show promise for cancer immunotherapy, but further clinical trials are needed to confirm their effectiveness and address potential side effects.
2022·40citations·P. Sasikumar et al.·Frontiers in Immunology
Frontiers in Immunology
Design, Synthesis, and Evaluation of o-(Biphenyl-3-ylmethoxy)nitrophenyl Derivatives as PD-1/PD-L1 Inhibitors with Potent Anticancer Efficacy In Vivo.
Compound B2 shows promising PD-1/PD-L1 inhibitory activity and potent anticancer efficacy in vivo, with potential for further development as a targeted therapy.
2021·34citations·Yiqiang Ouyang et al.·Journal of medicinal chemistry
Journal of medicinal chemistry