H. Fu, Leiqiang Han, Xuben Hou
Sep 1, 2015
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Influential Citations
13
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Quality indicators
Journal
Bioorganic & medicinal chemistry
Abstract
We report the development of a novel series of saccharin-based N-hydroxybenzamides as histone deacetylases inhibitors. Among them, 6 j exhibited potent HDACs inhibitory activity against Hela nuclear extract. Further biological evaluation found 6 i showed similar antiproliferative activities in vitro compared with the approved SAHA.