Sunil Vodela, R. Mekala, Ravinder Reddy Danda
Jul 1, 2013
Citations
0
Influential Citations
10
Citations
Journal
Chinese Chemical Letters
Abstract
Abstract A series of novel 2-(5-substituted-[1,3,4]oxadiazol-2-yl)-benzoxazoles ( 7a – h ) were synthesized in good yields in two different directions by involving benzoxazole-2-carboxylic acid ( 1 ) as raw material and benzoxazole-2-carbonyl chloride ( 2 ), benzoxazole-2-carboxylic acid methyl ester ( 3 ), benzoxazole-2-carboxylic acid hydrazide ( 4 ), benzoxazole-2-carboxylic acid N ′-acetyl hydrazide ( 5a – d ) and benzoxazole-2-carboxylic acid-ethylidene-hydrazides ( 6a – d ) as reactive intermediates. The chemical structures of all the synthesized compounds were elucidated by their IR, 1 H NMR and 13 C NMR and mass spectral data. Further, the target compounds were screened for their antimicrobial activity against various Gram-positive and Gram-negative bacteria.